Cardiovascular diseases, particularly acute myocardial infarction, are the leading cause of disability and death. Atherosclerosis, the pathological basis of AMI, can be accelerated by chronic inflammation. Ulcerative colitis (UC), a chronic inflammatory disease associated with immunity, contributes to the risk of AMI development. However, controversy continues to surround the relationship between these two diseases. The present study, published in the journal Cardiovascular Innovations and Applications, unravels the pathogenesis of AMI and UC, to provide a new perspective on the clinical management of patients with these comorbidities.