In a prospective cohort study including more than 360,000 people in Hong Kong, Dr. Andrea Luk and colleagues explore age-specific risk factors for all-cause and cause-specific mortality in type 2 diabetes.
Author summary Why was this study done? - In several countries, debates recently emerged regarding a potential banning of nitrites and nitrates as food additives. - While experimental studies are accumulating and seem to support a prohibiting strategy, epidemiological evidence regarding type 2 diabetes (T2D) risk remains unfortunately limited, yet seems important to develop given the suggested role of N-nitroso compounds in the development of insulin resistance. - Only 1 small prospective cohort study in Iran (n = 2,193) observed direct associations between higher dietary nitrite intakes and a higher T2D risk, in participants with low vitamin C intakes. However, this study did not distinguish between foods and water-originated nitrites and food additives-originated nitrites, and did not collect data on specific consumed brands. What did the researchers do and find? - We used appropriate statistical models to investigate, in the large prospective cohort NutriNet-Santé (n =
Tingting Geng and colleagues investigate whether lifestyle behaviours could affect microvascular complications among patients with type 2 diabetes in the UK Biobank.