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New Treatment Targets Specific Protein Regions in Medulloblastoma

New Treatment Targets Specific Protein Regions in Medulloblastoma
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Targeting specific protein regions offers a new treatment approach in medulloblastoma

Targeting specific protein regions offers a new treatment approach in medulloblastoma
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Targeting specific protein regions offers a new treatment approach in medulloblastoma

Explore how research targeting EP300/CBP protein in Group 3 medulloblastoma may advance targeted pediatric brain tumor treatments by inhibiting bromodomains.

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Melissa-ronan
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Targeting specific protein regions offers a new treatment approach in medulloblastoma

Explore how research targeting EP300/CBP protein in Group 3 medulloblastoma may advance targeted pediatric brain tumor treatments by inhibiting bromodomains.

Sarah-robinson
Audrey-mercier
Jennifer-roth
Qi-liu
Tingjian-wang
Brian-abraham
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Vanshita-goel
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Melissa-ronan

Brain mimetic co-culture reveals new targets in lung cancer brain metastases

Researchers at Kanazawa University, Japan, have reported a mixed-glial culture on/in soft substrate (MGS) platform to investigate cancer-glia interactions in vitro. Using this model, they showed that astrocytes favored brain metastasis by promoting metabotropic glutamate mGlu1 receptor (mGluR1) expression in cancer cells and stabilizing EGFR. Eishu Hirata, an associate professor at the Cancer Research Institute, Division of Tumor Cell Biology and Bioimaging at Kanazawa University, and his team published their work on Feb. 2, 2024, in Developmental Cell.

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Cancer
Non-small-cell-lung-cancer
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Astrocytes

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