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Study connects neural gene expression differences to functional distinctions

Study connects neural gene expression differences to functional distinctions
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Yulia akbergenovaCharles whittakerSuresh jettiKaren cunninghamNicole aponteTroy littletonPicower instituteNational institutes of healthCognitive sciencesPicower institute forMenicon professorAndres craneNicole aponte santiagoNational institutes

How Differences in Gene Expression Lead to Functionally Different Neurons

Researchers compared a pair of superficially similar motor neurons in fruit flies to examine how their differing use of the same genome produced distinctions in form and function.

Suresh jettiTroy littletonCognitive sciencesPicower institute forTechnology networkPicower instituteMolecular differencesFunctional variationMenicon professor

Study connects neural gene expression differences to functional distinctions

Study connects neural gene expression differences to functional distinctions
medicalxpress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medicalxpress.com Daily Mail and Mail on Sunday newspapers.

Troy littletonSuresh jettiSureshk jettiLittleton labCognitive sciencesPicower institute forPicower instituteMenicon professor

Key Protein Vital for Structural Integrity of Neurons – Without It Axons Break, Synapses Die

Key Protein Vital for Structural Integrity of Neurons – Without It Axons Break, Synapses Die
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Ellenj gussKarenl cunninghamKaren cunninghamJ troy littletonTroy littletonYulia akbergenovaCognitive sciencesNational institutes of healthLittleton labPicower institute forCourtesy of the littleton lab picower instituteNeuronal brain cell damage concept illustrationPicower instituteMenicon professorWithin broken neural axonGuss phd

Without a key extracellular protein, neuronal axons break and synaptic connections fall apart

MIT researchers found that without the protein perlecan, axonal segments in fruit flies can break apart during development. The synapses that they form end up dying away.

Yulia akbergenovaTroy littletonKaren cunninghamNational institutes of healthPicower institute forCognitive sciencesLittleton labPicower instituteMenicon professorGuss phdNational institutes