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04.23.21 Improved Bioavailability In 12 Weeks
An orally disintegrating tablet (ODT) is designed to rapidly dissolve on contact with saliva. This webinar presents the Zydis® ODT technology, a unique freeze-dried tablet, and introduces Zydis Ultra, which incorporates coated APIs for enhanced taste masking at a higher dose strength.
When Trio Medicines’ lead compound showed clinical promise but had limited bioavailability owing to low solubility, an integrated platform with a structured three-step approach substantially enhanced the bioavailability with a limited budget in a tight timeframe.
In this case study, a quality by design (QbD) approach was used to solve a high-performance liquid chromatography (HPLC) analytical method problem where impurity peaks had shifting retention times, making identification and quantitation problematic.
04.21.21 Improved Bioavailability In 12 Weeks
An orally disintegrating tablet (ODT) is designed to rapidly dissolve on contact with saliva. This webinar presents the Zydis® ODT technology, a unique freeze-dried tablet, and introduces Zydis Ultra, which incorporates coated APIs for enhanced taste masking at a higher dose strength.
When Trio Medicines’ lead compound showed clinical promise but had limited bioavailability owing to low solubility, an integrated platform with a structured three-step approach substantially enhanced the bioavailability with a limited budget in a tight timeframe.
In this case study, a quality by design (QbD) approach was used to solve a high-performance liquid chromatography (HPLC) analytical method problem where impurity peaks had shifting retention times, making identification and quantitation problematic.