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Process intensification is an essential component of Biopharma 4.0, a framework built on real-time monitoring, artificial intelligence, process optimization, and overall efficiency. Suppliers and sponsors are driving these initiatives, including through innovations in critical unit operations. Given that antibody drugs produced in mammalian (primarily CHO) expression systems comprise 75 percent of total biopharma sales, cell culture is the natural place to look for process efficiencies.

Trent munroNational biologics facilityUniversity of queensland