Stratford and District Chamber of Commerce hands out 2023 Business Excellence Awards mystratfordnow.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from mystratfordnow.com Daily Mail and Mail on Sunday newspapers.
Evolved Proteases Selectively Cleave Target Sequences, Unlock Potential of âProteome Editingâ
February 26, 2021
Engineered botulinum toxin could lead to new treatments for a range of maladies, including nerve and brain damage, muscle injury, and rampant inflammation.
[The Liu lab]
Share
Clostridium botulinum bacteria is responsible for producing botulinum toxin. As botox, it can remove wrinkles. It can also be the reason for a lethal human infection. Also known as the “miracle poison,” botulinum toxin has been approved by the FDA to treat a suite of maladies like chronic migraines, uncontrolled blinking, and certain muscle spasms.
Now, researchers have, for the first time, evolved botulinum neurotoxin proteases to selectively cleave new targets, including a protein unrelated to those natively cleaved by these proteases. In doing so, they have created a suite of bespoke, super-selective proteases with the potential to aid in neuroregeneration, regulate growth hor