Hepatitis is a global public health concern affecting millions of people worldwide. It is a viral infection that primarily targets the liver, causing inflammation and potentially leading to severe complications such as cirrhosis, liver cancer,.
BANDAR SERI BEGAWAN, Dec. 19 (Xinhua) Brunei logged a daily average of 332 new COVID-19 cases in the past week compared to 434 cases per day the week before,
BANDAR SERI BEGAWAN, Dec. 19 (Xinhua) Brunei logged a daily average of 332 new COVID-19 cases in the past week compared to 434 cases per day the week before,
In light of the increased popularity of phytocannabinoids (pCBs) and their appearance in beauty products without rigorous research on their rejuvenation efficacy, we decided to investigate the potential role of pCBs in skin rejuvenation. Utilizing healthy and stress-induced premature senescent (SIPS) CCD-1064Sk skin fibroblasts, the effects of pCBs on cellular viability, functional activity, metabolic function, and nuclear architecture were tested. Both delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) within the range of 0.5 µM to 2.0 µM increased cell growth in a dose-dependent manner while significantly decreasing senescence as measured by beta-galactosidase activity. Utilizing a scratch assay, both THC and CBD (2.0 µM) significantly improved wound healing in both healthy and SIPS fibroblasts. THC and CBD altered nuclear architecture and mRNA levels of cell cycle regulators and genes involved in ECM production. Subsequently, we found ELN, Cyclin