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Harmful effects of vaping and smoking, a comparable study

Scientists from the tobacco company Imperial Brands utilized Toxys' ToxTracker suite of stem-cell-based in-vitro assays to provided mechanistic insight into the potential DNA damaging properties of chemicals and compared the vape e-liquid samples and their aerosols with combustible cigarette smoke.

Scientists compare DNA damaging properties of chemicals from vape products and cigarettes

Scientists compare DNA damaging properties of chemicals from vape products and cigarettes Imperial Brands scientists have utilized Toxys ToxTracker suite of stem-cell based in-vitro assays, which provide mechanistic insight into the potential DNA damaging properties of chemicals, comparing vape e-liquid samples and their aerosols to combustible cigarette smoke. Imperial scientists are the first to publish results using the ToxTracker system for the assessment of vape e-liquids and aerosols, and it forms part of the company s continuing research into the tobacco harm reduction potential of Next Generation Products (NGPs) such as vapes. The assays help assess how product samples may impact cellular functioning across six reporter cell lines, picking up the tell-tale molecular signs of potential harm in the form of oxidative stress, DNA and protein damage, as well as activation of the p53 gene that has a role in cell cycle regulation and tumour suppression.

Vaping vs smoking: Impact on cells compared

 E-Mail IMAGE: Diagram showing the six reporter cells lines of the ToxTracker test, plus a wild type (wt) cell line used to visualise microscopic signs of DNA damage. view more  Credit: Toxys Imperial Brands scientists have utilised Toxys ToxTracker suite of stem-cell based in-vitro assays, which provide mechanistic insight into the potential DNA damaging properties of chemicals, comparing vape e-liquid samples and their aerosols to combustible cigarette smoke. Imperial scientists are the first to publish results using the ToxTracker system for the assessment of vape e-liquids and aerosols, and it forms part of the company s continuing research into the tobacco harm reduction potential of Next Generation Products (NGPs) such as vapes.

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