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UniQure Offers Update on Gene Therapy Study in Huntington s Disease

UniQure Offers Update on Gene Therapy Study in Huntington s Disease
globalgenes.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from globalgenes.org Daily Mail and Mail on Sunday newspapers.

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Annexon Reports Positive Phase 2 Results in Huntington s Disease

Annexon Reports Positive Phase 2 Results in Huntington s Disease
globalgenes.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from globalgenes.org Daily Mail and Mail on Sunday newspapers.

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Can Huntington s disease clinical trial design tweaks lead to success?

After a series of disappointing clinical trial data in Huntington’s disease, study design changes take aim at moving the field forward.

Neurocrine biosciencesPrilenia haydenAnnexon biosciencesPrelinia haydenChristopher rossLundbeck xenazineMichael haydenWave life sciencesPrilenia therapeuticsAnnexon bioscienceUnified huntingtonDisease rating scaleTotal functional capacityJohn hopkinsTotal motor scoreAlthough wave

New research supports pridopidine s neuroprotective properties in Huntington s Disease models

E-Mail Newly published papers further elucidate the mechanisms underlying pridopidine s neuroprotective properties through activation of the Sigma-1 Receptor (S1R). Pridopidine enhances mitochondrial function and reduces mHTT-induced ER stress, which are impaired in HD, mediated by the S1R. Three new peer-reviewed publications highlight pridopidine s therapeutic potential and provide data supporting the role of the S1R in neurodegenerative diseases Prilenia Therapeutics B.V., a clinical stage biotech company focused on developing novel treatments for neurodegenerative and neurodevelopmental disorders, today announces the publication of three peer-reviewed journal articles, highlighting key aspects of the mechanism of action of its lead asset, pridopidine, and the importance of S1R activation as a mechanism to attenuate biological features of neurodegenerative diseases.

Michaelr haydenHuntington study groupHealey centerInternational journal of molecular sciencesMediates pridopidine rescueMitochondrial functionHuntington disease modelsIts roleNeurodegenerative diseasesInternational journalMolecular sciencesAmyotrophic lateral sclerosisGlobal phaseTotal functional capacityMass generalHealth care

Prilenia Enrolls First Subject in Europe in its PROOF-HD Phase 3 Clinical Trial for Huntington s Disease

Prilenia Enrolls First Subject in Europe in its PROOF-HD Phase 3 Clinical Trial for Huntington s Disease About Prilenia (www.prilenia.com) Prilenia is a clinical stage biotech startup founded in 2018 with the purpose of improving the lives of patients and their families by developing treatments for neurodegenerative and neurodevelopmental disorders. Prilenia raised 88.5 million thus far and is backed by a group of well-respected investors: Talisman, Forbion, Morningside and Sectoral and ALS Investment Fund. The Company is based in Naarden, the Netherlands, Herzliya, Israel and Boston, MA in the U.S. About Pridopidine Prilenia s lead asset is Pridopidine, a first-in-class drug candidate with an established safety profile and therapeutic potential in several neurodegenerative diseases affecting adults and children. The highly selective S1R agonist was acquired from Teva in 2018.

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