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Csk Boosts Germinal Center B Cell Survival, Maturation

Csk Boosts Germinal Center B Cell Survival, Maturation
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The tyrosine kinase Csk promotes germinal center B cell survival and affinity maturation

Researchers from Osaka University found that the tyrosine kinase Csk plays a crucial role in regulating germinal center B cell signaling. Csk deletion in a mouse model led to increased ROS production and apoptosis, thereby inhibiting B cell affinity maturation.

Study finds tyrosine kinase Csk promotes germinal center B cell survival and affinity maturation

The immune system strikes a fine balance by identifying and neutralizing disease-causing agents while carefully avoiding destruction of healthy tissues and cells. Now, researchers from Japan have shed new light on one of the processes that helps train immune cells to act only against genuine threats.

STIM-Mediated Calcium Influx Guides B Cell Selection

STIM-Mediated Calcium Influx Guides B Cell Selection
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STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells: Study

STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells: Study
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