Mutations are changes in the molecular letters that make up the DNA code, the blueprint for all living cells. Some of these changes can have little effect, but others can lead to diseases, including cancer. Now, a new study introduces an original technique, called HiDEF-seq, that can accurately detect the early molecular changes in DNA code that precede mutations.
The Kansas City hospital has developed a process for performing whole-genome sequencing tests in the clinical setting. The next step is to use the data in clinical validation testing, says the director of its Genomic Medicine Center.