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New research sheds light on role of KRAS mutations in pancreatic cancer

Researchers at The University of Texas MD Anderson Cancer Center have uncovered a functional role for KRAS mutations in pancreatic cancer and rapidly translated these findings into a novel therapeutic approach combining a KRAS G12D inhibitor with immune checkpoint inhibitors for early- and late-stage KRAS G12D-mutant pancreatic cancer.

United statesSid richardsonKathleen mcandrewsRaghu kalluriKrishnan mahadevanAnirban maitraTimothy heffernanLily ramseyNational cancer instituteMd anderson translational research to advance therapeuticsKhalifa bin zayed al nahyan foundationLustgarten foundationOncology researchUniversity of texas md anderson cancer centerSidw richardson foundationCancer center

Combining immunotherapy with KRAS inhibitor eliminates advanced KRAS-mutant pancreatic cancer in preclinical models

Combining immunotherapy with KRAS inhibitor eliminates advanced KRAS-mutant pancreatic cancer in preclinical models
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United statesKrishnan mahadevanKathleen mcandrewsRaghu kalluriAnirban maitraTimothy heffernanMd anderson translational research to advance therapeuticsNational cancer instituteSidw richardson foundationKhalifa bin zayed al nahyan foundationLustgarten foundationOncology researchDevelopmental cellCancer cellCancer biologyTranslational molecular pathology

Combining immunotherapy with KRAS inhibitor eliminates advanced KRAS-mutant pancreatic cancer in preclinical models

Combining immunotherapy with KRAS inhibitor eliminates advanced KRAS-mutant pancreatic cancer in preclinical models
medicalxpress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medicalxpress.com Daily Mail and Mail on Sunday newspapers.

United statesAnirban maitraKathleen mcandrewsKrishnan mahadevanTimothy heffernanRaghu kalluriOncology researchUniversity of texas md anderson cancer centerMd anderson translational research to advance therapeuticsCancer centerDevelopmental celland cancer cellCancer biologyTranslational molecular pathologyTranslational researchAdvance therapeuticsDevelopmental cell

Immunotherapy-KRAS Combo Wipes Out Advanced Pancreatic Cancer

Immunotherapy-KRAS Combo Wipes Out Advanced Pancreatic Cancer
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United statesSid richardsonKathleen mcandrewsAnirban maitraTimothy heffernanKrishnan mahadevanRaghu kalluriOncology researchNational cancer instituteUniversity of texas md anderson cancer centerSidw richardson foundationKhalifa bin zayed al nahyan foundationLustgarten foundationMd anderson translational research to advance therapeuticsCancer centerDevelopmental cell

Combining immunotherapy with KRAS inhibitor e

Researchers at The University of Texas MD Anderson Cancer Center have uncovered a functional role for KRAS mutations in pancreatic cancer and rapidly translated these findings into a novel therapeutic approach combining a KRAS G12D inhibitor with immune checkpoint inhibitors for early- and late-stage KRAS G12D-mutant pancreatic cancer. The combination therapy led to durable tumor elimination and significantly improved survival outcomes in preclinical models, leading to the launch of a Phase I clinical trial.

United statesSid richardsonKrishnan mahadevanKathleen mcandrewsAnirban maitraTimothy heffernanRaghu kalluriNational cancer instituteAnderson translational research to advance therapeuticsUniversity of texas md anderson cancer centerLustgarten foundationKhalifa bin zayed al nahyan foundationSidw richardson foundationOncology researchCancer centerDevelopmental celland cancer cell