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True Hand Cannons: The 5 Largest Caliber Handguns Of All-Time

Which powerful weapons made the list (and which did not)? Back in 1971, Clint Eastwood took on a new role one that assured his transition from westerns to more contemporary settings and as San Francisco police detective “Dirty” Harry Callahan he uttered the famous passage, “This is a .44 Magnum, the most powerful handgun in the world, and would blow your head clean off, you’ve got to ask yourself one question: ‘Do I feel lucky?’ Well, do you, punk?” However, Callahan wasn’t actually correct, because a year earlier, the .44 Remington Magnum was actually eclipsed in size and power by the .454 Casull round. In the years since many there have been even more powerful handguns or should we say hand cannons to come onto the market.

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