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Beta-blockers show anti-inflammatory effects in cirrhosis Approximately 170,000 people die every year in Europe from the direct consequences of advanced chronic liver disease (cirrhosis). In Austria, cirrhosis of the liver is usually due to a fatty liver resulting from excessive alcohol consumption or overeating and/or poor diet and - thanks to effective antiviral therapies - less common due to viral hepatitis. Chronic liver damage leads to scarring (fibrosis) of the liver tissue, which can ultimately lead to increased blood pressure in the vascular system of the gastrointestinal tract (i.e. portal hypertension). Portal hypertension can result in serious complications such as ascites and variceal bleeding. A paper recently published by Thomas Reiberger s research group at MedUni Vienna has already shown that increasing severity of portal hypertension is paralleled by inflammatory reactions in the body (systemic inflammation). Pronounced systemic inflammation may ultimately trigger

Thomas reibergerMathias jachsEmily hendersonDepartment of internal medicineHepatology of the department medicineDivision of gastroenterologyVienna hepatic hemodynamic laboratoryClinical division of gastroenterologyUniversity of viennaMeduni viennaVienna generalClinical divisionInternal medicineMedical universityஎமிலி ஹென்டர்சன்துறை ஆஃப் உள் மருந்து