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Credit: UT Southwestern Medical Center DALLAS - Jan. 13, 2021 - A new treatment that combines two existing medications may provide long-sought relief for many battling debilitating methamphetamine use disorder, according to a study to be published tomorrow in The article, based on a multisite study funded by the National Institutes of Health (NIH), describes how combining an injectable drug currently used to treat alcohol and opioid addictions (naltrexone), and a commonly prescribed antidepressant (bupropion) produced positive results in 13.6 percent of the 403 patients treated, significantly higher than the 2.5 percent response in placebo groups. This is an important advance given that there are now no effective treatments for methamphetamine use disorder, says Madhukar Trivedi, M.D., a UT Southwestern professor of psychiatry and first author of the study.

United statesUniversity of california san franciscoSan franciscoThomas carmodyMadhukar trivediSidarth wakhluJuliek hershRobrina walkerDuke university school of medicineNational institute on drug abuseMental healthNational institute on drug abuse centerUniversity of south carolinaDepartment of healthTexas tech universityUniversity of minnesota