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Revealing Molecular Switches for Heart Disease

Revealing Molecular Switches for Heart Disease

How mitochondria make cut

© 2021 EPFL With the help of their custom-built super-resolution microscope, EPFL biophysicists have discovered where and why mitochondria divide, putting to rest controversy about the underlying molecular machinery of mitochondrial fission. Mitochondria either split in half or cut off their ends to self-regulate. The results are published in Nature. Mitochondria either split in half to multiply within the cell, or cut off their ends to get rid of damaged material. That’s the take-away message from EPFL biophysicists in their latest research investigating mitochondrial fission. It’s a major departure from the classical textbook explanation of the life cycle of this well-known organelle, the powerhouse of the cell. The results are published in Nature.

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