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Viruses Mutate, But Treatments Are Static. Is There a Way to Change That?
There is a big, global problem: viruses such as HIV and COVID-19 mutate, but treatments for them don’t.
For more than 20 years, Leor Weinberger, PhD, has been thinking about how to make vaccines work more efficiently by being adaptive, rather than static.
A human T cell (blue) is under attack by HIV (yellow), the virus that causes AIDS. Image by NIH
“We’re fighting biology with chemistry,” said Weinberger, director of the Gladstone Center for Cell Circuitry and a professor in the Departments of Pharmaceutical Chemistry and Biochemistry and Biophysics at UC San Francisco. “Biology is dynamic, so it evolves. It transmits. Chemistry does neither of those things. It’s static.”