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A pathway to personalized medicine and personalized biomanufacturing

Cell-free biotech enables shelf-stable vaccines on demand

February 3, 2021 Researchers from Cornell and Northwestern University have devised a new method of using extracts derived from bioengineered bacteria to create vaccines that protect against life-threatening infections caused by pathogenic bacteria. Because the technology can be easily reconfigured for different pathogenic foes and freeze-dried for portability and refrigeration-free storage, it could be a game-changing approach to fighting infection, especially in locations where access to such medicines is limited. Provided A collaboration between Cornell and Northwestern University has led to the creation of iVAX, which uses extracts derived from bioengineered bacteria to create shelf-stable vaccines on demand. The team’s paper, “On-Demand Biomanufacturing of Protective Conjugate Vaccines,” published Feb. 3 in Science Advances. The paper’s co-lead authors are Jessica Stark ’12, now a postdoctoral researcher at Stanford University, and doctoral student Thapakor

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