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Seladelpar normalizes ALP, reduces pruritis vs placebo in primary biliary cholangitis

Seladelpar normalizes ALP, reduces pruritis vs placebo in primary biliary cholangitis
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Gideonm hirschfieldTerry hornerHeather bieleBykate burbaUniversity of torontoTerry horner chairAutoimmune liver diseaseNew england journal

Genuinely exciting phase 3 results for CymaBay s seladelpar

Results from a phase 3 trial looking at treatment for primary biliary cholangitis (PBC) are 'genuinely exciting' and support the potential for seladelpar to raise the bar in treatment of the disease.

Charles mcwherterTerry hornerCymabay therapeutics incToronto centre for liver diseaseCymabay therapeuticsNew england journalGideon hirschfieldTerry horner chairToronto centreNew drug application

RESPONSE: Seladelpar Normalizes Alkaline Phosphatase, Reduces Pruritus in PBC

Results from the phase 3 trial showed seladelpar elicited biochemical response, normalized alkaline phosphatase, and reduced pruritus at a greater rate than placebo.

David assisTerry hornerGideon hirschfieldYale school of medicineAutoimmune liver disease researchDrug administrationUniversity of torontoFoundation gideon hirschfieldNew england journalYale schoolCymabay therapeutic new drug applicationPriority reviewPrescription drug user fee actTerry horner chairPrimary biliaryImproves markers

Pliant Therapeutics Announces Positive Safety and

Bexotegrast (PLN-74809) at 320 mg was well tolerated over 12 weeks of treatment with no drug-related severe or serious adverse events; No safety concerns.

United statesGideon hirshfieldChristopher keenanClin gastroenterol hepatolTerry hornerKrisv kowdleyUniversity of torontoCorporate communicationsLiver instituteClinical development nextDrug administrationEuropean medicines agencyPliant therapeutics incEnhanced liver fibrosisChief medical officerWell tolerated

Pliant Therapeutics Announces Positive Safety And Exploratory Efficacy Data From The INTEGRIS-PSC Phase 2A Trial Of Bexotegrast 320 Mg In Patients Wit

Pliant Therapeutics Announces Positive Safety And Exploratory Efficacy Data From The INTEGRIS-PSC Phase 2A Trial Of Bexotegrast 320 Mg In Patients Wit
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United statesClin gastroenterol hepatolTerry hornerChristopher keenanKrisv kowdleyGideon hirshfieldPliant therapeutics incEuropean medicines agencyDrug administrationCorporate communicationsUniversity of torontoLiver instituteClinical development nextEnhanced liver fibrosisChief medical officerWell tolerated