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Density matters for better battery material performance

Zinc cheap, abundant, environmentally friendly may be the answer to better batteries, but there’s a major problem: Aqueous zinc ion batteries (AZIBs) cannot match lithium-ion batteries in term .

Harnessing the Potential of High-Performance Organic Cathodes

Zinc, which is inexpensive, abundant, and ecologically friendly, could be the answer to better batteries, but there is a huge issue: In terms of power output, aqueous zinc ion batteries (AZIBs) cannot compete with lithium-ion batteries. To see what electrode material composition could bring AZIBs up to par, a Chinese research team created two organic frameworks with the same elements but arranged differently.

Pyrotinib versus placebo in combination with trastuzumab and docetaxel as first line treatment in patients with HER2 positive metastatic breast cancer (PHILA): randomised, double blind, multicentre, phase 3 trial

Objective To assess the efficacy and safety of pyrotinib (an irreversible pan-HER (human epidermal growth factor receptor) inhibitor), trastuzumab, and docetaxel compared with placebo, trastuzumab, and docetaxel for untreated HER2 positive metastatic breast cancer. Design Randomised, double blind, placebo controlled, multicentre, phase 3 trial. Setting 40 centres in China between 6 May 2019 and 17 January 2022. Participants 590 female patients (median age 52 (interquartile range 46-58) years) with untreated HER2 positive metastatic breast cancer. Interventions Eligible patients were randomised 1:1 to receive either oral pyrotinib (400 mg once daily) or placebo, both combined with intravenous trastuzumab (8 mg/kg in cycle 1 and 6 mg/kg in subsequent cycles) and docetaxel (75 mg/m2) on day 1 of each 21 day cycle. Randomisation was stratified by treatment history of trastuzumab in the (neo)adjuvant setting and hormone receptor status. Patients, investigators, and the sponsor’s study

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