A major mystery in Alzheimerâs disease research is why some brain cells succumb to the creeping pathology of the disease years before symptoms first appear, while others seem impervious to the degeneration surrounding them until the diseaseâs final stages. Â
An image of human brain samples used to study why some brain cells are more vulnerable to Alzheimerâs disease than others.
Image by Rana Eser, UCSF Grinberg lab
Now, in a study published Jan. 10, 2021, in
Nature Neuroscience, a team of molecular biologists and neuropathologists from the UCSF Weill Institute for Neurosciences have joined forces to identify for the first time the neurons that are among the first victims of the disease ââ¯accumulating toxic âtanglesâ and dying off earlier than neighboring cells. Â
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In aggressive pursuit of its vision of a world without Alzheimer’s and all other dementia, the Association once again made its
largest-ever research investment in FY20,
granting more than $47 million to 139 new scientific investigations. Investments included awards to 119 projects funded through the
International Research Grant Program, representing proposals ranked highest by a peer-reviewed process in a highly competitive field of 406 applications submitted from 865 letters of intent. As the world’s leading nonprofit funder of Alzheimer’s and dementia research, the Association is currently investing $208 million in more than 590 active best-of-field projects in 31 countries.
The Association paused funding programs in March 2020 after hearing significant challenges from potential applicants in submitting their necessary documents for consideration as a result of the COVID-19 pandemic. The Association continues to be in touch with multi
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