Our genetic code includes over 15,000 specific sections that can be made into molecules called lincRNAs. Some of these sections can occur in coiled-up sections of our genome called TADs. LincRNAs derived from TADs appear to act as markers indicating the specific kind of tissue they are within. When something is wrong in these tissues, the markers could help with targeted medical interventions. The team that discovered this novel feature has outlined a way to apply this idea to different diseases and demonstrated it with a heart disease known as hypertrophic cardiomyopathy.