We have no shortage of lovely summer weather across the mediterranean late summer weather is you have your minds eye further north sorry much like or some bands of clouds lots of rain and some pretty strong winds brisk winds rattling in once again across the northwest of running right across the British Isles the low countries across a good part of scandinavia. In london so the academic 18 so were going to feel anything like that when you get on the strength of that wind 15 celsius there for berlin we push across towards those eastern parts of moscow struggles to get to 11 degrees so lets head back down to the summer getting up to 2728 degrees over the next couple days after this may even touch 29 on monday those blustery showers the blustery conditions they continue. Filtering across northern parts as we go through monday further south fine dry and sunny sums it up madrid 30 degrees celsius and that sunshine that extends across northern parts of africa is chewed a similar conditions h
Objective To determine whether a single low dose of esketamine administered after childbirth reduces postpartum depression in mothers with prenatal depression.
Design Randomised, double blind, placebo controlled trial with two parallel arms.
Setting Five tertiary care hospitals in China, 19 June 2020 to 3 August 2022.
Participants 364 mothers aged ≥18 years who had at least mild prenatal depression as indicated by Edinburgh postnatal depression scale scores of ≥10 (range 0-30, with higher scores indicating worse depression) and who were admitted to hospital for delivery.
Interventions Participants were randomly assigned 1:1 to receive either 0.2 mg/kg esketamine or placebo infused intravenously over 40 minutes after childbirth once the umbilical cord had been clamped.
Main outcome measures The primary outcome was prevalence of a major depressive episode at 42 days post partum, diagnosed using the mini-international neuropsychiatric interview. Secondary outcomes included the Ed