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Recurrent DCIS Not Always Related to Primary Tumor

New research has challenged the assumption that recurrence of ductal carcinoma in situ always originates from the initial tumor.

DCIS Recurrence Often Represents a New Primary Breast Cancer

Recurrent DCIS Can Be Genetically Distinct From Primary Lesion

Recurrent noninvasive breast tumors may not always be related to primary lesion

Recurrent noninvasive breast tumors may not always be related to primary lesion
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Recurrent ductal carcinoma in situ tumors often genetically distinct from primary lesion

A substantial portion of ductal carcinoma in situ recurrences did not appear genetically related to their primary lesions, according to study findings presented at American Association for Cancer Research Annual Meeting.De novo tumors with distinct genetic alterations accounted for nearly two in 10 recurrences, the detailed molecular analysis showed.

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