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Kanazawa University research: Bacteria in heat--high temperatures facilitate fermentation

Share this article KANAZAWA, Japan, April 27, 2021 /PRNewswire/ In a study published in Applied Microbiology and Biotechnology biologists at Kanazawa University report an increase in the synthesis of fermentation products in bacteria at high reaction temperatures. Mankind has long relied on fermentation the metabolic processes within microorganisms to procure useful compounds such as lactic acid (found in yogurt and kimchi) and ethanol (present in that daily glass of wine). Corynebacterium glutamicum is a bacterium used for industrial scale production of lactic acid and succinic acid, which can be used as bio-based plastic monomers. To-date, fermentation in C. glutamicum is conducted at temperatures of ~30°C, wherein the bacterium can grow comfortably. Now, Hikaru Mizuno and Yota Tsuge from Kanazawa University show that the production efficiency of some fermentation products can instead be magnified by simply increasing the reaction temperature above growth thresholds.

Kanazawa University research: Leg muscle action assists blood flow independently of age

Kanazawa University research: Leg muscle action assists blood flow independently of age KANAZAWA, Japan, April 27, 2021 /PRNewswire/ Researchers at Kanazawa University report in the Japan Journal of Nursing Science; a study of muscle pump action in the context of chronic lower-limb edema. They found that body posture and exercise habits affect the blood pumping action of muscles in the leg, whereas age generally does not. Chronic lower-limb edema (CLE) - the permanent accumulation of fluid in the leg - often occurs in elderly people. The condition leads to various physical and mental problems, including difficulty in walking or moving, fatigue and anxiety. One cause of CLE is the lack of physical activity, which is associated with a decrease in muscle pump action. The latter refers to the leg muscle s acting as a blood pump: when contracted, the muscle squeezes veins together, forcing blood to flow. The question whether muscle pump action systematically changes with age has not b

Kanazawa University research: Tracing tumors: targeting and imaging cancer cells

Share this article KANAZAWA, Japan, April 27, 2021 /PRNewswire/ In a recent study published in the journal Molecules researchers at Kanazawa University describe the use of novel gallium-based radiotracers to visualize tumors in the body. Cancer cells highly express specific proteins on their surface which helps oncologists identify and target these cells. For example, platelet-derived growth factor receptor β (PDGFRβ) which is often found on breast and colon cancer cells has been used to design probes that can attach to it and facilitate imaging of these cells. All such tracers designed to date have shown low accumulation within tumor tissues making it hard to visualize the cancer accurately. However, a team led by Kazuma Ogawa at Kanazawa University has now used radiolabeled gallium (Ga) to create tracers which showed potential when tested in mice.

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