It is now three months since the Sweden striker last kicked a ball for his new club following a £60million move from Real Sociedad. Isak injured his thigh on international duty in September.
With home advantage on their side, England will be slight favourites going into Tuesday night s game. But the Swedes are the highest ranked team in the competition.
Sweden s standout stars include captain Magda Eriksson, who became an unlikely LGBT role model when she and her girlfriend Pernille Harder shared an on-pitch kiss in 2019 that went viral.