<p>We all know someone who's had a head injury that was "only" a concussion, but even mild traumatic brain injuries can cause lasting damage, and the vast majority are never diagnosed. A team led by Samir Mitragotri at the Wyss Institute, Harvard SEAS, and Boston Children's Hospital created a way to diagnose mild TBIs (mTBIs) even when MRI scans showed nothing, using the body's own immune cells called macrophages. They attached microparticle "backpacks" containing a common MRI contrast agent to the cells, which migrated to the brain and allowed them to see evidence of inflammation in pigs with a mock mTBI.</p>
Shining a light on the hidden damage of mild brain injuries
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Illuminating Hidden Harm of Mild Brain Injuries
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<p>We all know someone who's had a head injury that was "only" a concussion, but even mild traumatic brain injuries can cause lasting damage, and the vast majority are never diagnosed. A team led by Samir Mitragotri at the Wyss Institute, Harvard SEAS, and Boston Children's Hospital created a way to diagnose mild TBIs (mTBIs) even when MRI scans showed nothing, using the body's own immune cells called macrophages. They attached microparticle "backpacks" containing a common MRI contrast agent to the cells, which migrated to the brain and allowed them to see evidence of inflammation in pigs with a mock mTBI.</p>