For bleeding patients, can cold storage of platelets improve blood clotting?
$26 million in funding to help determine whether cold platelets can reduce blood loss more effectively than those stored at room temperature
The image illustrates platelets, which are essential for normal blood clotting in the body. Platelets are the focus of a large, multicenter study led by researchers at Washington University School of Medicine in St. Louis and the University of Minnesota Medical School in Minneapolis. The researchers want to know whether maintaining platelets in cold storage is as effective in reducing blood loss as platelets stored at room temperature and whether the shelf life of cold platelets can be safely extended to 21 days. (Image: Getty Images)
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The image illustrates platelets, which are essential for normal blood clotting in the body. Platelets are the focus of a large, multicenter study led by researchers at Washington University School of Medicine in St. Louis and the University of Minnesota Medical School in Minneapolis. The researchers want to know whether maintaining platelets in cold storage is as effective in reducing blood loss as platelets stored at room temperature and whether the shelf life of cold platelets can be safely extended to 21 days.
Patients undergoing complex cardiac surgery are at risk of excessive bleeding, a life-threatening complication that can occur during or after the operation and often requires a transfusion of platelets. Platelets help blood clot, preventing blood loss.
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A lead author, Peter Pronovost, MD, PhD, Chief Quality and Clinical Transformation Officer at University Hospitals and Clinical Professor of Anesthesiology and Critical Care Medicine at Case Western Reserve University in Cleveland, developed the concept of defects in value. He and co-first author John W. Urwin, MD, of Beth Israel Deaconess Medical Center, Harvard Medical School, and the Department of Medical Ethics and Health Policy, University of Pennsylvania, wrote their model offers a hopeful path forward for improving value in health care.
Using the success achieved at University Hospitals (UH) in Cleveland where annual costs per patient in the UH Accountable Care Organization (ACO) were reduced by 9 percent over the course of 12 months researchers demonstrated that deploying a framework in which specific defects in value were eliminated could not only save money but improve the overall care value proposition. In the UH ACO, they applied this framework to the 37,000