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Early Identification of Autism Spectrum Disorder Among Children Aged 4 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2020

This report describes CDC findings from the Autism and Developmental Disabilities Monitoring Network for children aged 4 years in 2020.

University of utahUnited statesUniversity of arkansasNew yorkOak ridgeWashington universityLittle rockUniversity of arizonaUniversity of minnesotaNew jerseySan diegoUniversity of wisconsinVanderbilt universitySalt lake cityMonica dirienzoPatricia colan

Frontiers | High-throughput sequencing reveals the presence of novel and known viruses in diseased Paris yunnanensis

Viral diseases of Paris spp. have become serious problems in cultivation of this group of important medicinal plants in China. In this study, eight viruses were identified in the diseased plants of Paris yunnanensis by high-throughput sequencing (HTS) and RT-PCR. These viruses include three novel viruses (two potyviruses and one nepovirus), Hippeastrum chlorotic ringspot virus (HCRV)，Lychnis mottle virus (LycMoV), Paris mosaic necrosis virus (PMNV), Paris virus 1 and pepper mild mottle virus. The three new viruses were tentatively named Paris potyvirus 3 (ParPV-3), Paris potyvirus 4 (ParPV-4), Paris nepovirus 1 (ParNV-1) and their complete genome sequences were determined. Sequence analyses showed ParPV-3 and ParPV-4 shared the highest amino acid (aa) sequence identities of 54.3% to each other and 53.0-57.8% to other known potyviruses. ParNV-1 had aa sequence identities of 28.8-63.7% at protease-polymerase (Pro-Pol) with other nepoviruses. Phylogenetic analyses further support that t

United statesFrance generalPotyviridae adamsPotyvirus chenBetaflexiviridae dongSecoviridae dullemansCucurbitaceae xuParidis rhizomaJacq salisbVpg polPotyvirus yangVirgaviridae wenTobamovirus chenSecoviridae thompsonClustal omegaNational science foundation of china

Predicting major complications in patients undergoing laparoscopic and open hysterectomy for benign indications

Background: Hysterectomy, the most common gynecological operation, requires surgeons to counsel women about their operative risks. We aimed to develop and validate multivariable logistic regression models to predict major complications of laparoscopic or abdominal hysterectomy for benign conditions. Methods: We obtained routinely collected health administrative data from the English National Health Service (NHS) from 2011 to 2018. We defined major complications based on core outcomes for postoperative complications including ureteric, gastrointestinal and vascular injury, and wound complications. We specified 11 predictors a priori. We used internal–external cross-validation to evaluate discrimination and calibration across 7 NHS regions in the development cohort. We validated the final models using data from an additional NHS region. Results: We found that major complications occurred in 4.4% (3037/68 599) of laparoscopic and 4.9% (6201/125 971) of abdominal hysterectomies. Our mo

United kingdomUnited statesWest midlandsUnited kingdom generalCity ofKhalid khanSilvia fernandez garciaBorja fernandez felixKrupa madhvaniBeatriz galindoJavier zamoraEnglish national health serviceData access request serviceClassification of surgical operationsDrug administrationUniversity of granada

Tiny discovery in Chinese lab could be a big deal in stopping Covid-19

Tiny discovery in Chinese lab could be a big deal in stopping Covid-19
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A multi-country, prospective cohort study to measure rate and risk of relapse among children recovered from severe acute malnutrition in Mali, Somalia, and South Sudan: a study protocol | BMC Nutrition

The Community-Based Management of Acute Malnutrition (CMAM) model transformed the treatment of severe acute malnutrition (SAM) by shifting treatment from inpatient facilities to the community. Evidence shows that while CMAM programs are effective in the initial recovery from SAM, recovery is not sustained for some children requiring them to receive treatment repeatedly. This indicates a potential gap in the model, yet little evidence is available on the incidence of relapse, the determinants of the phenomena, or its financial implications on program delivery. This study is a multi-country prospective cohort study following “post-SAM” children (defined as children following anthropometric recovery from SAM through treatment in CMAM) and matched community controls (defined as children not previously experiencing acute malnutrition (AM)) monthly for six months. The aim is to assess the burden and determinants of relapse to SAM. This study design enables the quantification of r

South sudanWilayat shimal bahr al ghazalUnited statesDemocratic republic of the congoBahr el ghazalWilayat gharb bahr al ghazalMinistry of healthBanadir regionIntegrated food security phase classificationAction against hungerEast countyAweil eastAction againstHousehold hunger scaleAdditional fileOpen data kit