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Visual dexterity: In-hand reorientation of novel and complex object shapes

Visual dexterity: In-hand reorientation of novel and complex object shapes
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Common sense machines incLincoln laboratory supercomputing centerToyota research instituteUs airTutor intelligence incNational science foundation graduate research fellowshipImprobable ai laboratoryWatson ai labIntel realsenseSupplementary discussionIsaac gymMinkowski engineUnified robot description formatCovariance matrix adaptation evolution strategyCommon senseNational science foundation graduate research

Unavoidable future increase in West Antarctic ice-shelf melting over the twenty-first century

Ocean-driven melting of floating ice-shelves in the Amundsen Sea is currently the main process controlling Antarctica’s contribution to sea-level rise. Using a regional ocean model, we present a comprehensive suite of future projections of ice-shelf melting in the Amundsen Sea. We find that rapid ocean warming, at approximately triple the historical rate, is likely committed over the twenty-first century, with widespread increases in ice-shelf melting, including in regions crucial for ice-sheet stability. When internal climate variability is considered, there is no significant difference between mid-range emissions scenarios and the most ambitious targets of the Paris Agreement. These results suggest that mitigation of greenhouse gases now has limited power to prevent ocean warming that could lead to the collapse of the West Antarctic Ice Sheet. The authors use a regional ocean model to project ocean-driven ice-shelf melt in the Amundsen Sea. Already committed rapid ocean warming

France generalAmundsen seaExtended dataExtended data tableSupplementary discussion

Complete human day 14 post-implantation embryo models from naïve ES cells

The ability to study human post-implantation development remains limited due to ethical and technical challenges associated with intrauterine development after implantation1. Embryo-like models with spatially organized morphogenesis of all defining embryonic and extra-embryonic tissues of the post-implantation human conceptus (i.e., embryonic disk, bilaminar disk, yolk- and chorionic sacs, surrounding trophoblasts) remain lacking2. Mouse naïve embryonic stem cells (ESCs) have recently been shown to give rise to embryonic and extra-embryonic stem cells capable of self-assembling into post-gastrulation mouse Structured Stem cell-based Embryo Models with spatially organized morphogenesis (SEMs)3. Here, we extend these findings to humans, while using only genetically unmodified human naïve ESCs (in HENSM conditions)4. Such human fully integrated SEMs recapitulate the organization of nearly all known lineages and compartments of post-implantation human embryos including epiblast,

Supplementary figuresSupplementary introductionSupplementary discussionExtended data

Vitrification and nanowarming enable long-term organ cryopreservation and life-sustaining kidney transplantation in a rat model

Banking cryopreserved organs could transform transplantation into a planned procedure that more equitably reaches patients regardless of geographical and time constraints. Previous organ cryopreservation attempts have failed primarily due to ice formation, but a promising alternative is vitrification, or the rapid cooling of organs to a stable, ice-free, glass-like state. However, rewarming of vitrified organs can similarly fail due to ice crystallization if rewarming is too slow or cracking from thermal stress if rewarming is not uniform. Here we use “nanowarming,” which employs alternating magnetic fields to heat nanoparticles within the organ vasculature, to achieve both rapid and uniform warming, after which the nanoparticles are removed by perfusion. We show that vitrified kidneys can be cryogenically stored (up to 100 days) and successfully recovered by nanowarming to allow transplantation and restore life-sustaining full renal function in nephrectomized reci

University of wisconsinSupplementary dataSupplementary discussionFresh controlSupplementary methodsHenseleit bufferSource data