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A Wyss Institute-led collaboration spanning four research labs and hundreds of miles has used the Institute s organ-on-a-chip (Organ Chip) technology to identify the antimalarial drug amodiaquine as a potent inhibitor of infection with SARS-CoV-2, the virus that causes COVID-19.
The Organ Chip-based drug testing ecosystem established by the collaboration greatly streamlines the process of evaluating the safety and efficacy of existing drugs for new medical applications, and provides a proof-of-concept for the use of Organ Chips to rapidly repurpose existing drugs for new medical applications, including future pandemics. The research is reported in
Nature Biomedical Engineering.
While many groups around the world have been testing existing drugs for efficacy against COVID-19 using cultured cells, it is well known that cells grown in a dish do not behave like the cells in a living human body, and many drugs that appear effective in lab studies do not work in patients. T
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(HealthNewsDigest.com) - LA JOLLA, CALIF. – April 16, 2021 – Scientists at Sanford Burnham Prebys have identified a set of human genes that fight SARS-CoV-2 infection, the virus that causes COVID-19. Knowing which genes help control viral infection can greatly assist researchers’ understanding of factors that affect disease severity and also suggest possible therapeutic options. The genes in question are related to interferons, the body’s frontline virus fighters.
The study was published in the journal
“We wanted to gain a better understanding of the cellular response to SARS-CoV-2, including what drives a strong or weak response to infection,” says Sumit K. Chanda, Ph.D., professor and director of the Immunity and Pathogenesis Program at Sanford Burnham Prebys and lead author of the study. “We’ve gained new insights into how the virus exploits the human cells it invades, but we are still searching for its Achille’s heel so that we can develop optimal antivir
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Credit: Dotted Yeti
LA JOLLA, CALIF. - April 16, 2021 - Scientists at Sanford Burnham Prebys have identified a set of human genes that fight SARS-CoV-2 infection, the virus that causes COVID-19. Knowing which genes help control viral infection can greatly assist researchers understanding of factors that affect disease severity and also suggest possible therapeutic options. The genes in question are related to interferons, the body s frontline virus fighters.
The study was published in the journal
Molecular Cell. We wanted to gain a better understanding of the cellular response to SARS-CoV-2, including what drives a strong or weak response to infection, says Sumit K. Chanda, Ph.D., professor and director of the Immunity and Pathogenesis Program at Sanford Burnham Prebys and lead author of the study. We ve gained new insights into how the virus exploits the human cells it invades, but we are still searching for its Achille s heel so that we can develop optimal antivirals.
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United-states
San-diego
University-of-california-san-diego
Maryk-lewinski
Meganl-shaw
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Matthew-urbanowski
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Mark-becker
Charlottea-stoneham
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