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Frontiers | Paleoseismological Findings at a New Trench Indicate the 1714 M8 1 Earthquake Ruptured the Main Frontal Thrust Over all the Bhutan Himalaya
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Physicochemical failure modes for Narrow Therapeutic Index (NTI) drugs
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COVID-19: Neuer Wirkmechanismus von Remdesivir entdeckt
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Date Time
SARS-CoV-2 Research: Second possible effective mechanism of remdesivir discovered
The virostatic agent remdesivir was developed to disrupt an important step in the propagation of RNA viruses, to which SARS-CoV-2 also belongs: the reproduction of the virus’s own genetic material. This is present as RNA matrices with which the host cell directly produces virus proteins. To accelerate the production of its own proteins, however, RNA viruses cause the RNA matrices to be copied. To do so, they use a specific protein of their own (an RNA polymerase), which is blocked by remdesivir. Strictly speaking, remdesivir does not do this itself, but rather a substance that is synthesized from remdesivir in five steps when remdesivir penetrates a cell.