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In an early phase multicenter study, reductions in lipoprotein(a) to undetectable levels were achieved with a small interfering RNA therapeutic, lepodisiran.

United statesLos angelesMichellel odonoghueStevene nissenDonald lloyd jonesKarol watsonJournal of the american medical associationDepartment of preventive medicineLerner college of medicine at cleveland clinicAmerican heart association scientific sessionsGeffen school of medicineLerner collegeCleveland clinicStrongly associated withAmerican medicalNew england journal