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16 of this world cup. health chiefs urge parents of toddlers to vaccinate their children against the flu, after an increase in hospital admissions. close to collapsing into chaos. that is the warning from business leaders across the north of england, where 80% of rail services have been cancelled this year. they say it could get worse before christmas. then they re is meeting the government later to say enough is enough. another grey, misty and cold day across most of the uk. a few sunny spots. good morning. it s wednesday, the 30th of november. a major trial of an experimental dementia drug has shown, for the first time, that the progression of early stage alzheimer s disease can be slowed down. nearly 2,000 patients took part in the study, including some in the uk.
perfect drug, but in a very modest way it perfect drug, but in a very modest way it can perfect drug, but in a very modest way it can slow the decline from alzheimer s. so even though it is very modest, that is highly significant. very modest, that is highly siunificant. , significant. and they say is an international significant. and they say is an international story significant. and they say is an international story in - significant. and they say is an international story in lots - significant. and they say is an international story in lots of l significant. and they say is an - international story in lots of ways, isn t it? some of the trials took place in the uk but they were across the world. in practical terms, people who are watching this morning, what do they need to know about when this might eventually arrive here and be available? yes. arrive here and be available? yes, it was an international arrive here and be available? yes, it was an international trial. -
in memory and understanding. david is one of nearly 2,000 patients who took part in a major trial of a new drug lecanemab. as normal, if you just - lift your arm up there for me. it involved having an infusion every two weeks. lecanemab didn t stop alzheimer s. i lljust get you started here. ..but over 18 months, it s slowed its progression by about a quarter. this is so exciting because now we re getting results, - the first results that - are indicating that the drug is successfully treating the underlying cause and is slowing down the symptoms of cognitive impairment, and also the behavioural symptoms associated with alzheimer s disease. david and his wife cheryl can t be sure if the drug is making a difference, but they re delighted to have taken part in the trial. when we first began this two and a half years ago, we didn t necessarily think it
no, it s not. so, some of those who took no, it s not. so, some of those who took part no, it s not. so, some of those who took part suffered brain swelling and also took part suffered brain swelling and also bleeds in the brain. so patients and also bleeds in the brain. so patients need to be carefully monitored. but i can tell you that the patients i might like david, and another the patients i might like david, and another couple, who didn t know whether another couple, who didn t know whether they were on the drug initially, whether they were on the drug initially, or on the dummy drug, because initially, or on the dummy drug, because those involved, there were 2000 because those involved, there were 2000 patients, completely blinded trial, they were so delighted to be part of trial, they were so delighted to be part of it trial, they were so delighted to be part of it. and now everybody who took part part of it. and now everybody who took part in part of it. an