Can the microbiome predict Parkinsonâs?
Written by Jocelyn Solis-Moreira on February 7, 2021 â Fact checked by Alexandra Sanfins, Ph.D.
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A study finds that Parkinsonâs disease is associated with changes in the composition of the gut microbiome.
In Parkinsonâs disease, the gut bacteriaâs ability to break down fat is altered, making it harder to regulate bile acid production.
Disruptions in bile acid production could be a potential indicator of the condition.
Treatments targeting the microbiome and bile acids may help delay the progression of Parkinsonâs disease.
The gut microbiome influences many systems of the body.
What does bile acid production in the digestive tract have to do with Parkinson’s disease? Quite a lot, according to a study published in
The findings reveal that changes in the gut microbiome may in turn alter bile acid production by favoring synthesis of toxic forms of the acids.
These shifts were seen only in people with Parkinson’s and not in healthy controls, a critical difference that suggests bile acids may be a viable biomarker for diagnosing Parkinson’s early and tracking its progression. The insights also may provide new avenues for developing therapies that impede Parkinson’s-related changes in the gut, thereby potentially slowing or stopping disease onset and progression, a media release from Van Andel Research Institute explains.
Metabolites. The findings reveal that changes in the gut microbiome the rich population of helpful microbes that call the digestive tract home may in turn alter bile acid production by favoring synthesis of toxic forms of the acids.
These shifts were seen only in people with Parkinson s and not in healthy controls, a critical difference that suggests bile acids may be a viable biomarker for diagnosing Parkinson s early and tracking its progression. The insights also may provide new avenues for developing therapies that impede Parkinson s-related changes in the gut, thereby potentially slowing or stopping disease onset and progression.
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