Researchers have discovered a protein that is the missing link in the complicated chain of events that lead to Alzheimer s disease. They also found that blocking the protein with an existing drug can restore memory in mice with brain damage that mimics the disease.
An analysis prefrontal cortex cell types in four primate species find human-specific features ones that also make us susceptible to neuropsychiatric diseases.
What makes human brain different? Yale study reveals clues miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.
Neurons Regenerated through Suppression of Regeneration-Thwarting Genes
March 2, 2021
Using a massive screen of 400 mouse genes, Yale School of Medicine researchers identified 40 genes that thwart axon regeneration in central nervous system cells. By suppressing those genes, the researchers were able to regenerate damaged axons in a mouse model of glaucoma, that is, in mice that had been subjected to optic nerve crush. Suppression of one of the genes the gene for the cytokine interleukin-22 (IL-22) proved to be especially effective in promoting regeneration.
“This opens a new chapter in regeneration research,” said Stephen M. Strittmatter, MD, PhD, the Vincent Coates professor of neurology at the Yale School of Medicine. To support this assertion, Strittmatter and colleagues presented their findings in an article (“Optic nerve regeneration screen identifies multiple genes restricting adult neural repair”) that appeared March 2 in