Metabolic syndrome that develops in middle age had a greater association with osteoarthritis knee symptoms and pain than metabolic syndrome that resolved or persistent metabolic syndrome in a recent study.
Interventions such as electrophysical stimulation and acupuncture don t appear to offer much benefit in reducing pain or improving physical function even when used to supplement exercise therapy.
Although some patients benefit from antidepressants for osteoarthritis pain, it s difficult to know which patients will benefit and which will be more likely to experience harm.