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Tramadol in widely used for noncancer pain but as compared with codeine, it was associated with a higher risk for adverse outcomes, including death.

Northwestern universityUnited statesUnited kingdomComunidad autonoma de catalunaCarlen reyesJordi golHowards kimInstitut universitariDivision of rheumatologyAmerican academy of orthopaedic surgeonsHarvard medical schoolAmerican academyOrthopaedic surgeonsDaniel solomonPain managementPain management