The road to effective cancer vaccines has been long and difficult. Although initial attempts to use a vaccine to treat cancer date back to the 1910s, the first effective therapeutic vaccine would not emerge until about a century later, when Sipuleuce
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At a pivotal moment in cancer vaccine research, the MIT Koch Institute Annual Symposium explored emerging successes and obstacles in the field in areas that include immunology, next-generation tools and models, and mRNA and other vaccine platforms.
In an advance that could help scientists learn more about cancer-linked mutations whose roles are not known, MIT researchers have developed a way to easily engineer specific cancer-linked mutations into mouse models, using CRISPR prime editing.