Few animal experiments and volunteer-based intervention studies have showed a controversial effect of spicy foods on abdominal obesity. We aimed to examine the association between spicy food frequency, spicy flavor, and abdominal obesity among Chinese Han population in the Sichuan Basin which area eating spicy foods relatively often. A cross-sectional analysis was conducted using the Sichuan Basin baseline data from the China Multi-Ethnic Cohort (CMEC) study, including data from electronic questionnaires, anthropometric measurements and blood sample collection. A total of 40,877 adults (22,503 females) aged 30–79 years were included in the final analysis. Multivariable logistic regression yielded adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for abdominal obesity associated with the strength of spicy flavor and frequency of spicy food intake. The prevalence of daily spicy food eating was 47.3% in males and 52.7% in females, the percentages of abdominal ob
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H) CCND1 expression in BC patients revealed by GEPIA website (
I) the β-catenin and GSK3β expression as well as the extent of GSK3β phosphorylation in MCF-7 and T47D parents and resistant cells. Data are displayed in the form of mean ± SD. All experiments were repeated at least three times. In panel (
B) two-way ANOVA along with Tukey’s multiple comparison was applied, while in panel (
D, E and
p 0.05,
p 0.01.
Abbreviations: miR, microRNA; FOXO1, forkhead box O1; CCND1, cyclin D1; SD, standard deviation; ANOVA, analysis of variance.
We predicted that FOXO1 could bind to the promoter sequence of CCND1 through the JASPAR website (