A novel derivative of ciprofloxacin (Cpx) was synthesized and characterized using various analytical techniques, including FT-IR spectroscopy, UV-Vis spectroscopy, TEM and SEM analysis, 1H NMR, 13C NMR, and HPLC analysis. The newly prepared Cpx derivative (Cpx-Drv) exhibited significantly enhanced antibacterial properties compared to Cpx itself. In particular, Cpx-Drv demonstrated a 51% increase in antibacterial activity against S. aureus and a 30% improvement against B. subtilis. It displayed potent inhibitory effects on topoisomerases II (DNA gyrase and topoisomerase IV) as potential molecular targets, with IC50 values of 6.754 and 1.913 µg/mL, respectively, in contrast to Cpx, which had IC50 values of 2.125 and 0.821 µg/mL, respectively. Docking studies further supported these findings, showing that Cpx-Drv exhibited stronger binding interactions with the gyrase enzyme (PDB ID: 2XCT) compared to the parent Cpx, with binding affinities of −10.3349 and −7.7506
IHG Hotels & Resorts has signed a management agreement with Mabany Edris, a well-known real estate owner and developer in Egypt, to open Holiday Inn New Assiut Asayla.
IHG
® Hotels & Resorts, one of the world s leading hotel companies, has signed a Management Agreement with Mabany Edris, a well-known real estate owner and developer in Egypt, to open Holiday Inn New Assiut Asayla. The hotel was signed at a ceremony in Egypt in presence of Abdel Fattah Al-Assi, Assistant Minister of Tourism and Antiquities and Mohamad Anwar, Deputy Head of Urban Communities Authorities. IHG has a strong legacy in Egypt, having opened its first hotel in 1980s, and currently operates over 2000 rooms and have more than 800 rooms in the pipeline, across brands.
The announcement follows several high-profile signings this year, across IHG luxury and lifestyle, premium, essentials and suites collections, underscoring the company s progressive expansion plans across the MEA region. Further, the signing strengthens IHG s mainstream portfolio in MEA, in line with demands across key markets in the region.
IHG Expands Footprint In Egypt With Signing Of Holiday Inn New Assiut Asayla – Hospitality Net hospitalitynet.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from hospitalitynet.org Daily Mail and Mail on Sunday newspapers.