Picodroplet technology is a transformative single cell analysis technique based on the rapid encapsulation of individual cells in miniaturized, picoliter-volume, water-in-oil droplets (picodroplets). Each picodroplet serves as a miniature test tube, providing the ability to screen single cells in their own microenvironment with increased precision and sensitivity. This format provides a uniquely protective environment to support cell viability and integrity during incubation, and shield cells
Picodroplet microfluidics is rapidly becoming the technology of choice for single-cell analysis, providing an easy-to-use tool to encapsulate single cells in picolitre-volume aqueous droplets (picodroplets) at high throughput rates of thousands of droplets per second. This powerful and sensitive technique offers significant cost and efficiency advantages. An additional advantage of this approach is that picodroplets provide a cell friendly culturing environment. Depending on the assay and app
In this article, Sphere Fluidics demonstrates how they perform rapid and efficient cell screening of IgG-secreting mammalian cells in order to isolate high-producing clones.
In this article, Sphere Fluidics demonstrates how its Cyto Mine instrument can conduct a high-throughput method for identifying rare antigen secreting cells from B cell repertoires and hybridoma fusions.