Oak Brook, IL - The April edition of
SLAS Discovery is a special issue on advances in protein degradation curated by guest editors M. Paola Castaldi, Ph.D., and Stewart L. Fisher, Ph.D.
Targeted protein degradation has generated interest within the drug discovery arena due to the inhibition of one particular function of a protein not often delivering the successful results that comes from whole-protein depletion. The pharmacology of PROTACs present challenges, however, namely for the development of orally bioavailable drugs. In the article Target Validation Using PROTACs: Applying the Four Pillars Framework authors Rados?aw P. Nowak, Ph.D., and Lyn H. Jones, Ph.D., describe the application of a translational pharmacology framework (the four pillars) to expedite PROTAC development by informing pharmacokinetic-pharmacodynamic (PKPD) understanding and helping clarify structure-activity relationships. Nowak and Jones hope that the four pillars will serve as a useful guideline to th
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Oak Brook, IL - The March edition of
SLAS Discovery features the cover article, Therapeutic and Vaccine Options for COVID-19: Status After 6 Months of the Disease Outbreak by Christian Ogaugwu (Federal University Oye-Ekiti, Ekiti State, Nigeria ), Dawid Maciorowski, Subba Rao Durvasula, Ph.D., Ravi Durvasula, M.D., and Adinarayana Kunamneni, Ph.D. (Loyola University Medical Center, Maywood, IL, USA).
This cover article focuses on the therapeutic and vaccine options available against the novel coronavirus, roughly six months after the outbreak; because the COVID-19-related death toll worldwide had reached 500,000 in six months (and ballooned to over 2,000,000 at the time of publishing) the importance of options to temper the disease cannot be overemphasized. The article highlights the available treatment alternatives for mild and serious active cases of COVID-19 infections and explores the vaccine options that should aid to confer immunity to vaccinated individuals. In addition
The Society for Laboratory Automation and Screening (SLAS) is pleased to announce David McIntyre, Ph.D. candidate from Boston University (Boston, MA, USA), as the 2021 SLAS Graduate Education Fellowship Grant recipient.
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Oak Brook, IL - The Society for Laboratory Automation and Screening (SLAS) is pleased to announce a collaboration with the Pistoia Alliance to support and promote innovative life sciences start-ups and emerging companies.
The SLAS Ignite Program is a multi-pronged initiative to promote innovation, pioneering research, start-up and emerging companies and their products, and commercialization and collaboration opportunities for all involved. Through Innovation AveNEW and the Ignite Award, Ignite Academic Collaborations and other activities, SLAS underscores its foundational commitment to enabling scientists, academic researchers and business development professionals to build relationships as potential strategic partners.
The Pistoia Alliance is a global organization made up of life science companies, technology and service providers, publishers, and academic groups working together to lower barriers to innovation in life science and healthcare R&D. Its President s Start