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Aldosterone Synthase Inhibition With Lorundrostat for Uncontrolled Hypertension

This randomized clinical trial assesses the effect of 5 dosages of lorundrostat treatment vs placebo on 8-week systolic blood pressure change among adults with

United statesCatalys pacificStevene nissenNovo nordiskGroup informationGordy healthBristol myers squibbLucidact healthClinical researchBoehringer ingelheimTanabe pharmaceuticalsAmerican heart association hypertension scientific sessionsInstitute incAmsterdam pharmaceuticalsCleveland clinic coordinating centerBetween july

Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial | Dementia and Cognitive Impairment | JAMA

This randomized clinical trial examines the efficacy and adverse effects of donanemab, a monoclonal antibody designed to clear brain amyloid plaque, among patie

Eteläuomen läiLisaann trembathGwen xuLinda shurzinskeAdam schaumDedeepya masarapuJung kimStacya huckinsCarmen deveauRashna khannaAndrea abramWei zhouJanssen cilagNaohisa hatekeyamaDeirdre hobanHrideep antony

Letermovir vs Valganciclovir for Prophylaxis of Cytomegalovirus in High-Risk Kidney Transplant Recipients: A Randomized Clinical Trial | Infectious Diseases | JAMA

This randomized clinical trial compares the efficacy and safety of letermovir vs valganciclovir prophylaxis for cytomegalovirus (CMV) disease in CMV-seronegativ

United statesUniversity of washingtonSan diegoAjitp limayeMerck co incMerck coEuropean medicines agencyAmerican society of nephrology kidney weekGilead sciencesMerck sharp dohmeAmerican transplant congressDrug administrationGood clinical practiceInternational conferenceHarmonization guidelineSecondary efficacy outcomes

Direct Oral Anticoagulants vs Low-Molecular-Weight Heparin and Recurrent VTE in Patients With Cancer: A Randomized Clinical Trial | JAMA

This randomized trial assesses the comparative effectiveness of direct oral anticoagulants vs low-molecular-weight heparin on rate of 6-month recurrence of veno

Memorial sloan kettering cancer centerNew yorkUnited statesGenentech rocheQuinn johnstonAstellas pharmaDeborah schragAlliance foundation trialsCovington burlingBlood instituteBristol myers squibbAlliance for clinical trials in oncologyOutcomes research instituteDrug administrationNational institutes of healthOr foundation

Panitumumab vs Bevacizumab Added to Standard First-line Chemotherapy and Overall Survival Among Patients With RAS Wild-type, Left-Sided Metastatic Colorectal Cancer: A Randomized Clinical Trial | Colorectal Cancer | JAMA

This randomized clinical trial assesses the effect of adding panitumumab vs bevacizumab to standard first-line chemotherapy on overall survival among patients w

United statesEteläuomen läiSolasia pharmaMarko rehnTakayuki yoshinoMerck seronoLela creutzYakult honshaMerck biopharmaYukiko sakakibaraBayer yakuhinKaken pharmaLauren gallagherMichelle mcdermottEli lillyAsahi kasei

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