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Study shows pharmacological rescue of mitochondrial defect related to Parkinson s disease Treating mice that have a Parkinson s disease-causing mutation with a small molecule compound restores the removal of damaged mitochondria from their brain cells, shows a study published today in eLife. The findings may help explain what goes wrong in dopamine-producing brain cells in people with mutations that cause Parkinson s disease. Parkinson s disease is caused by the progressive loss of brain cells that produce dopamine. This causes the hallmark symptoms of the disease, including tremors, rigid movements, sleep problems and dementia. Scientists believe the death of these cells in people with Parkinson s disease is caused, in part, by the failure of a quality control mechanism that removes damaged energy-producing structures in the cells called mitochondria. This failure to recycle damaged mitochondria is detrimental to the health of brain cells.

United kingdomFrancois singhEmily hendersonIan ganleyResearch council protein phosphorylationDivision of signal transduction therapyScientific programme leaderUniversity of dundeePostdoctoral researchFirst authorPostdoctoral research assistantMedical research council protein phosphorylationUbiquitylation unitSignal transduction therapyஒன்றுபட்டது கிஂக்டம்எமிலி ஹென்டர்சன்