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Researchers at The University of Texas MD Anderson Cancer have engineered a new model of aggressive renal cell carcinoma (RCC), highlighting molecular targets and genomic events that trigger chromosomal instability and drive metastatic progression. The study, published today in Nature Cancer, demonstrates that the loss of a cluster of interferon receptor (IFNR) genes plays a pivotal role in allowing cancer cells to become tolerant of chromosomal instability. This genomic feature may be used to help clinicians predict a tumor’s potential to become metastatic and treatment resistant.

United statesUnited kingdomLuigi perelliRicerca sul cancroHorne jrGiannicola genovesePancreatic cancer action network incNational institutes of healthUs department of defenseKidney cancer associationBruce krier prostate cancer research endowment fundUnited kingdom medical research councilLyda hill foundationUniversity of texas md anderson cancerBarbara massie memorial fundProfessorship for cancer research