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Tenofovir Vaginal Rings May Best Dapivirine for Cyclic HIV Protection

HIV Protection, Birth Control Levels Vary in Studies of Vaginal Rings Advertisement To date, no head-to-head trial has compared the prevention methods. This article has been updated to reflect additional information and for clarity. Separate trials of vaginal rings for HIV and pregnancy prevention found that levels of topical dapivirine and tenofovir drop at different rates during periodic removal, according to data presented at the 4th HIV Research for Prevention virtual conference. In a trial of a 90-day vaginal ring loaded with dapivirine, levels of the drug in vaginal fluid dropped “precipitously” during periodic removal. Meanwhile, the drops were not as steep in rings loaded with tenofovir, even when the rings were removed for an extra day.

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