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New Approach Allows Researchers To Hit Undruggable Cancer Target

A protein degrader shows potential in targeting STAT5, a protein involved in leukemia and other forms of cancer. For decades, researchers have been interested in targeting the protein STAT5 in the fight against cancer. However, despite extensive efforts, STAT5 was eventually considered "undruggable

United statesHoda metwallyShaomeng wangRenqi xuAtsunori kaneshigeDonna mceachernFemi wangMeilin wangYu wangDuxin sunJenniferl meagherWei jiangJeannea stuckeyProteovant roivantLongchuan baiHui jiang

Protein degradation approach can be used to hit an undruggable target against cancer

The protein STAT5 has long been an appealing target against cancer, but after decades of research it was consigned to the "undruggable" category.

United statesShaomeng wangEmily hendersonUniversity of michigan rogel cancer centerUniversity of michiganMichigan rogel cancer centerParke davis professorNature chemicalCancer treatment

THE PROSTATE CANCER FOUNDATION ANNOUNCES INAUGURAL $30 MILLION TACTICAL AWARDS PROGRAM FOR INNOVATIVE PROSTATE CANCER RESEARCH

/PRNewswire/ The Prostate Cancer Foundation (PCF) today announced four inaugural Class of 2022 TACTICAL (Therapy ACceleration To Intercept CAncer Lethality).

United kingdomYu chenUnited statesUniversity of southern californiaUniversity of pennsylvaniaYi xingUniversity of california san franciscoSan franciscoJames gulleySalomon tendlerAnna pacelliMichael hofmanChristine monaKen herrmannAlex tsodikovStacil vernick

This molecule could be behind liver fibrosis

This molecule could be behind liver fibrosis
scienceblog.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from scienceblog.com Daily Mail and Mail on Sunday newspapers.

Louisg dalecySuthat liangpunsakulAnnas lokChong shenZhiguo zhangLiang shengM bishr omaryXiao zhongLiangyou ruiShaomeng wangNature communicationsSchool department of molecular integrative physiologyNon alcoholic steatohepatitisAlecy collegiate professorUm medical school department

Ascentage Pharma International : The Journal of Medicinal Chemistry Publishes Study Showing Potential of the Potent EED Inhibitor EEDi-5273 (APG-5918) to Achieve Complete Tumor Regression by Modulating the Epigenetics

SUZHOU, China, and ROCKVILLE, Md., Oct. 18, 2021 /PRNewswire/ Ascentage Pharma , a global biopharmaceutical company engaged in developing novel therapies for cancers, chronic hepatitis B , and. | October 18, 2021

Hong kongWestern australiaUnited statesDajun yangAscentage pharmaPrnewswire ascentage pharmaShaomeng wangMajor nationalMd anderson cancer centerDana farber cancer instituteUniversity of michiganChief scientific advisorParke davis professorInternal medicineMedicinal chemistryInvestigational new drug

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