HAp bioceramics with micro-nano-hybrid surface and Sr doping had synergistic promotion effects on bone regeneration, a promising material for bone defect repair
Chemotherapy drugs can induce mutations that lead to relapse in pediatric ALL patients
Chemotherapy has helped make acute lymphoblastic leukemia (ALL) one of the most survivable childhood cancers. Now, researchers working in the U.S., Germany and China have shown how chemotherapy drugs called thiopurines can lead to mutations that set patients up for relapse. The work appears today in the journal
Nature Cancer.
The research provides the first direct genomic and experimental evidence in pediatric cancer that drug-resistant mutations can be induced by chemotherapy and are not always present at diagnosis.
The findings offer a paradigm shift in understanding how drug resistance develops. The results also suggest possible treatment strategies for ALL patients who relapse, including screening to identify those who should avoid additional thiopurine treatment.
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IMAGE: (a) Flat-wrinkle-tripling-fold transition with substrate precompression; (b) flat-wrinkle-doubling-quadrupling-fold transformation under direct compression; (c) flat-wrinkle-ridge transition with substrate pre-stretch and large modulus ratio; (d) flat-wrinkle-hierarchical transition with substrate pre-stretch and small. view more
Credit: @Science China Press
Surface instability of compliant film/substrate bilayers has raised considerable interests due to its broad applications such as wrinkle-driven surface renewal and antifouling, shape-morphing for camouflaging skins, and micro/nano-scale surface patterning control. However, it is still a challenge to precisely predict and continuously trace secondary bifurcation transitions in the nonlinear post-buckling region. Fundamental understanding and quantitative prediction of morphological evolution and pattern selection are, in fact, crucial for the effective use of wrinkling as a tool for morphological desi